| 251 | St Thomas More High School | 1,206 pupils | Academy · Day · 6th | Westcliff-on-Sea, East of England | — |
| 252 | Passmores Academy | 1,205 pupils | Academy · Day | Harlow, East of England | — |
| 253 | Lift New Rickstones | 1,204 pupils | Academy · Day · 6th | Witham, East of England | — |
| 254 | King Edward VI CEVC School | 1,199 pupils | State · Day | Bury St Edmunds, East of England | — |
| 255 | Saint Joan of Arc Catholic School | 1,199 pupils | Academy · Day · 6th | Rickmansworth, East of England | — |
| 256 | Sawston Village College | 1,194 pupils | Academy · Day | Cambridge, East of England | — |
| 257 | Putteridge High School | 1,192 pupils | Academy · Day | Luton, East of England | — |
| 258 | King Edward VII Academy | 1,181 pupils | Academy · Day · 6th | King's Lynn, East of England | — |
| 259 | Hertswood Academy | 1,173 pupils | Academy · Day · 6th | Borehamwood, East of England | — |
| 260 | Hedingham School and Sixth Form | 1,155 pupils | Academy · Day · 6th | Halstead, East of England | — |
| 261 | Queensbury Academy | 1,154 pupils | Academy · Day · 6th | Dunstable, East of England | — |
| 262 | The Eastwood Academy | 1,143 pupils | Academy · Day | Leigh-on-Sea, East of England | — |
| 263 | Becket Keys Church of England Free School | 1,140 pupils | Free School · Day · 6th | Brentwood, East of England | — |
| 264 | Dereham Neatherd High School | 1,139 pupils | Academy · Day · 6th | Dereham, East of England | — |
| 265 | The Bromfords School | 1,135 pupils | Academy · Day · 6th | Wickford, East of England | — |
| 266 | Chesterton Community College | 1,129 pupils | Academy · Day · 6th | Cambridge, East of England | — |
| 267 | Saint Michael's Catholic High School | 1,121 pupils | Academy · Day · 6th | Watford, East of England | — |
| 268 | Aylsham High School | 1,108 pupils | State · Day | Norwich, East of England | — |
| 269 | Kings Langley School | 1,104 pupils | Academy · Day · 6th | Kings Langley, East of England | — |
| 270 | Sir Harry Smith Community College | 1,104 pupils | Academy · Day · 6th | Peterborough, East of England | — |
| 271 | Sawtry Village Academy | 1,085 pupils | Academy · Day · 6th | Huntingdon, East of England | — |
| 272 | John F Kennedy Catholic School | 1,078 pupils | Academy · Day · 6th | Hemel Hempstead, East of England | — |
| 273 | Ormiston Rivers Academy | 1,077 pupils | Academy · Day · 6th | Burnham-on-Crouch, East of England | — |
| 274 | Alec Hunter Academy | 1,067 pupils | Academy · Day | Braintree, East of England | — |
| 275 | Hartismere School | 1,051 pupils | Academy · Day · 6th | Eye, East of England | — |