| 251 | Deyes High School | 1,355 pupils | Academy · Day · 6th | Liverpool, North West | — |
| 252 | Dean Trust Ardwick | 1,339 pupils | Academy · Day | Manchester, North West | — |
| 253 | Ulverston Victoria High School | 1,336 pupils | State · Day · 6th | Ulverston, North West | — |
| 254 | Dixons Middleton Academy | 1,333 pupils | Academy · Day | Manchester, North West | — |
| 255 | Knutsford Academy | 1,325 pupils | Academy · Day · 6th | Knutsford, North West | — |
| 256 | St Matthew's RC High School | 1,324 pupils | Academy · Day | Manchester, North West | — |
| 257 | Kingsway Park High School | 1,320 pupils | Academy · Day | Rochdale, North West | — |
| 258 | Witton Park Academy | 1,312 pupils | Academy · Day | Blackburn, North West | — |
| 259 | William Howard School | 1,303 pupils | Academy · Day · 6th | Brampton, North West | — |
| 260 | Saints Peter and Paul Catholic High School | 1,302 pupils | State · Day | Widnes, North West | — |
| 261 | Dixons Ashton Academy | 1,299 pupils | Academy · Day | Ashton-under-Lyne, North West | — |
| 262 | Accrington St Christopher's Church of England High School | 1,293 pupils | Academy · Day · 6th | Accrington, North West | — |
| 263 | Standish Community High School | 1,292 pupils | Academy · Day | Wigan, North West | — |
| 264 | Fred Longworth High School | 1,288 pupils | Academy · Day | Manchester, North West | — |
| 265 | Hope Academy | 1,288 pupils | Academy · Day | Newton-le-Willows, North West | — |
| 266 | North Liverpool Academy | 1,286 pupils | Academy · Day · 6th | Liverpool, North West | — |
| 267 | Cockermouth School | 1,285 pupils | Academy · Day · 6th | Cockermouth, North West | — |
| 268 | E-ACT the Oldham Academy North | 1,284 pupils | Academy · Day | Oldham, North West | — |
| 269 | Co-op Academy North Manchester | 1,258 pupils | Academy · Day · 6th | Manchester, North West | — |
| 270 | All Hallows Catholic College | 1,251 pupils | Academy · Day · 6th | Macclesfield, North West | — |
| 271 | Helsby High School | 1,235 pupils | State · Day · 6th | Frodsham, North West | — |
| 272 | Dixons Broadgreen Academy | 1,230 pupils | Academy · Day · 6th | Liverpool, North West | — |
| 273 | Matthew Moss High School | 1,221 pupils | Academy · Day | Rochdale, North West | — |
| 274 | Sharples School | 1,218 pupils | Academy · Day | Bolton, North West | — |
| 275 | Ormskirk School | 1,212 pupils | Academy · Day · 6th | Ormskirk, North West | — |