| 1751 | Stoke Newington School and Sixth Form | 1,647 pupils | State · Day · 6th | London, London | — |
| 1752 | Whalley Range 11-18 High School | 1,647 pupils | Academy · Day · 6th | Manchester, North West | — |
| 1753 | Calthorpe Park School | 1,644 pupils | State · Day | Fleet, South East | — |
| 1754 | Didcot Girls' School | 1,643 pupils | Academy · Day · 6th | Didcot, South East | — |
| 1755 | Holly Lodge High School College of Science | 1,643 pupils | State · Day · 6th | Smethwick, West Midlands | — |
| 1756 | Cardinal Newman Catholic School A Specialist Science College | 1,641 pupils | Academy · Day · 6th | Luton, East of England | — |
| 1757 | Wymondham High Academy | 1,639 pupils | Academy · Day · 6th | Wymondham, East of England | — |
| 1758 | Otley Prince Henry's Grammar School Specialist Language College | 1,638 pupils | Academy · Day · 6th | Otley, Yorkshire and the Humber | — |
| 1759 | Blatchington Mill School | 1,635 pupils | State · Day | Hove, South East | — |
| 1760 | Grey Court School | 1,631 pupils | Academy · Day · 6th | Richmond, London | — |
| 1761 | Carlton Bolling | 1,630 pupils | Academy · Day | Bradford, Yorkshire and the Humber | — |
| 1762 | Chesterfield High School | 1,628 pupils | Academy · Day · 6th | Liverpool, North West | — |
| 1763 | King Edward VI School | 1,627 pupils | State · Day · 6th | Lichfield, West Midlands | — |
| 1764 | Ringwood School Academy | 1,626 pupils | Academy · Day · 6th | Ringwood, South East | — |
| 1765 | Rainham School for Girls | 1,625 pupils | Academy · Day · 6th | Gillingham, South East | — |
| 1766 | Park View School | 1,617 pupils | Academy · Day · 6th | Chester le Street, North East | — |
| 1767 | Abbey Grange Church of England Academy | 1,615 pupils | Academy · Day · 6th | Leeds, Yorkshire and the Humber | — |
| 1768 | Thomas Gainsborough School | 1,615 pupils | Academy · Day · 6th | Sudbury, East of England | — |
| 1769 | Blessed Thomas Holford Catholic College | 1,614 pupils | State · Day · 6th | Altrincham, North West | — |
| 1770 | Ryburn Valley High School | 1,614 pupils | Academy · Day · 6th | Sowerby Bridge, Yorkshire and the Humber | — |
| 1771 | The Chalk Hills Academy | 1,614 pupils | Academy · Day · 6th | Luton, East of England | — |
| 1772 | Lift Greensward | 1,613 pupils | Academy · Day · 6th | Hockley, East of England | — |
| 1773 | Co-op Academy Manchester | 1,610 pupils | Academy · Day | Manchester, North West | — |
| 1774 | Goffs Academy | 1,606 pupils | Academy · Day · 6th | Waltham Cross, East of England | — |
| 1775 | Beckfoot School | 1,605 pupils | Academy · Day · 6th | Bingley, Yorkshire and the Humber | — |