| 401 | Cardinal Allen Catholic High School, Fleetwood | 783 pupils | State · Day | Fleetwood, North West | — |
| 402 | Prenton High School for Girls | 781 pupils | Academy · Day | Birkenhead, North West | — |
| 403 | North Cestrian School | 777 pupils | Free School · Day | Altrincham, North West | — |
| 404 | Lostock Hall Academy | 773 pupils | Academy · Day | Preston, North West | — |
| 405 | Holy Family Roman Catholic and Church of England College | 763 pupils | State · Day | Heywood, North West | — |
| 406 | Brownedge St Mary's Catholic High School | 760 pupils | State · Day | Preston, North West | — |
| 407 | Bolton Muslim Girls School | 752 pupils | Academy · Day | Bolton, North West | — |
| 408 | All Hallows RC High School | 737 pupils | State · Day | Salford, North West | — |
| 409 | The Brian Clarke Church of England Academy | 719 pupils | Free School · Day | Oldham, North West | — |
| 410 | Ruskin Community High School | 715 pupils | State · Day | Crewe, North West | — |
| 411 | St Bede's Catholic High School | 706 pupils | State · Day | Ormskirk, North West | — |
| 412 | Dean Trust Rose Bridge | 699 pupils | Academy · Day | Wigan, North West | — |
| 413 | Sir William Stanier School | 688 pupils | Academy · Day | Crewe, North West | — |
| 414 | Carnforth High School | 685 pupils | Academy · Day | Carnforth, North West | — |
| 415 | Rhyddings | 683 pupils | Academy · Day | Accrington, North West | — |
| 416 | Tarleton Academy | 675 pupils | Academy · Day | Preston, North West | — |
| 417 | Sacred Heart Catholic Academy | 653 pupils | Academy · Day · 6th | Liverpool, North West | — |
| 418 | Whitworth Community High School | 651 pupils | State · Day | ROCHDALE, North West | — |
| 419 | St Thomas More Catholic High School | 647 pupils | Academy · Day | Crewe, North West | — |
| 420 | Eden Boys' School, Bolton | 623 pupils | Free School · Day | Bolton, North West | — |
| 421 | Academy@Worden | 618 pupils | Academy · Day | Leyland, North West | — |
| 422 | Eden Boys' School, Preston | 617 pupils | Free School · Day | Preston, North West | — |
| 423 | Preston Muslim Girls High School | 608 pupils | State · Day | Preston, North West | — |
| 424 | Burnley High School | 607 pupils | Free School · Day | Burnley, North West | — |
| 425 | University Collegiate School | 604 pupils | Free School · Day · 6th | Bolton, North West | — |