| 276 | Calday Grange Grammar School | 1,479 pupils | Grammar · Day · 6th | Wirral, North West | — |
| 277 | Tytherington School | 1,416 pupils | Academy · Day · 6th | Macclesfield, North West | — |
| 278 | Woodchurch High School | 1,415 pupils | Academy · Day | Wirral, North West | — |
| 279 | Brine Leas School | 1,411 pupils | Academy · Day · 6th | Nantwich, North West | — |
| 280 | The Deanery Church of England High School and Sixth Form College | 1,372 pupils | State · Day · 6th | Wigan, North West | — |
| 281 | Wardle Academy | 1,364 pupils | Academy · Day | Rochdale, North West | — |
| 282 | Falinge Park High School | 1,359 pupils | Academy · Day | Rochdale, North West | — |
| 283 | Deyes High School | 1,355 pupils | Academy · Day · 6th | Liverpool, North West | — |
| 284 | Dean Trust Ardwick | 1,339 pupils | Academy · Day | Manchester, North West | — |
| 285 | Ulverston Victoria High School | 1,336 pupils | State · Day · 6th | Ulverston, North West | — |
| 286 | Dixons Middleton Academy | 1,333 pupils | Academy · Day | Manchester, North West | — |
| 287 | Knutsford Academy | 1,325 pupils | Academy · Day · 6th | Knutsford, North West | — |
| 288 | St Matthew's RC High School | 1,324 pupils | Academy · Day | Manchester, North West | — |
| 289 | Kingsway Park High School | 1,320 pupils | Academy · Day | Rochdale, North West | — |
| 290 | Witton Park Academy | 1,312 pupils | Academy · Day | Blackburn, North West | — |
| 291 | William Howard School | 1,303 pupils | Academy · Day · 6th | Brampton, North West | — |
| 292 | Saints Peter and Paul Catholic High School | 1,302 pupils | State · Day | Widnes, North West | — |
| 293 | Dixons Ashton Academy | 1,299 pupils | Academy · Day | Ashton-under-Lyne, North West | — |
| 294 | Accrington St Christopher's Church of England High School | 1,293 pupils | Academy · Day · 6th | Accrington, North West | — |
| 295 | Standish Community High School | 1,292 pupils | Academy · Day | Wigan, North West | — |
| 296 | Fred Longworth High School | 1,288 pupils | Academy · Day | Manchester, North West | — |
| 297 | Hope Academy | 1,288 pupils | Academy · Day | Newton-le-Willows, North West | — |
| 298 | North Liverpool Academy | 1,286 pupils | Academy · Day · 6th | Liverpool, North West | — |
| 299 | Cockermouth School | 1,285 pupils | Academy · Day · 6th | Cockermouth, North West | — |
| 300 | E-ACT the Oldham Academy North | 1,284 pupils | Academy · Day | Oldham, North West | — |